Pubmed Publications

• Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment.
• Mamdouh Z, Mikhailov A, Muller WA The Journal of experimental medicine 2009 Nov 23; 206(12):2795-808 PMID: 19887395
• Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment.
• Mamdouh Z, Kreitzer GE, Muller WA The Journal of experimental medicine 2008 Apr 14; 205(4):951-66 PMID: 18378793
• Locomotion of monocytes on endothelium is a critical step during extravasation.
• Schenkel AR, Mamdouh Z, Muller WA Nature immunology 2004 Apr; 5(4):393-400 PMID: 15021878

• Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis.
• Mamdouh Z, Chen X, Pierini LM, Maxfield FR, Muller WA Nature 2003 Feb 13; 421(6924):748-53 PMID: 12610627
• Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity.
• Privratsky JR, Paddock CM, Florey O, Newman DK, Muller WA, Newman PJ Journal of cell science 2011 May 1; 124(Pt 9):1477-85 PMID: 21486942
• Phosphorylation of leukocyte PECAM and its association with detergent-resistant membranes regulate transendothelial migration.
• Florey O, Durgan J, Muller W Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 1; 185(3):1878-86 PMID: 20581150
• Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins block distinct steps in transendothelial migration of effector memory CD4+ T cells by targeting different endothelial proteins.
• Manes TD, Hoer S, Muller WA, Lehner PJ, Pober JS Journal of immunology (Baltimore, Md. : 1950) 2010 May 1; 184(9):5186-92 PMID: 20357254
• Blocking platelet/endothelial cell adhesion molecule 1 (PECAM) inhibits disease progression and prevents joint erosion in established collagen antibody-induced arthritis.
• Dasgupta B, Chew T, deRoche A, Muller WA Experimental and molecular pathology 2010 Feb; 88(1):210-5 PMID: 19800878
• Mechanisms of Leukocyte Transendothelial Migration.
• Muller WA Annual review of pathology 2010 Jan 15; : PMID: 21073340
• Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry.
• Early MA, Lishnevsky M, Gilchrist JM, Higgins DM, Orme IM, Muller WA, Gonzalez-Juarerro M, Schenkel AR Experimental and molecular pathology 2009 Oct; 87(2):152-8 PMID: 19646434
• Mechanisms of transendothelial migration of leukocytes.
• Muller WA Circulation research 2009 Jul 31; 105(3):223-30 PMID: 19644057
• A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration.
• Dasgupta B, Dufour E, Mamdouh Z, Muller WA Journal of immunology (Baltimore, Md. : 1950) 2009 Apr 15; 182(8):5041-51 PMID: 19342684
• Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages.
• Westhorpe CL, Zhou J, Webster NL, Kalionis B, Lewin SR, Jaworowski A, Muller WA, Crowe SM Journal of leukocyte biology 2009 Mar 13; : PMID: 19286896
• PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2.
• Seidman MA, Chew TW, Schenkel AR, Muller WA PLoS ONE 2009; 4(1):e4316 PMID: 19180231
• Endothelial Src kinase regulates membrane recycling from the lateral border recycling compartment during leukocyte transendothelial migration.
• Dasgupta B, Muller WA European journal of immunology 2008 Dec; 38(12):3499-507 PMID: 18991269
• CD99 is essential for leukocyte diapedesis in vivo.
• Dufour EM, Deroche A, Bae Y, Muller WA Cell communication & adhesion 2008 Nov; 15(4):351-63 PMID: 18923973
• Tonsilar NK cells restrict B cell transformation by the Epstein-Barr virus via IFN-gamma.
• Strowig T, Brilot F, Arrey F, Bougras G, Thomas D, Muller WA, Münz C PLoS pathogens 2008 Feb 8; 4(2):e27 PMID: 18266470
• Assays of transendothelial migration in vitro.
• Muller WA, Luscinskas FW Methods in enzymology 2008; 443:155-76 PMID: 18772016
• CD99 is a key mediator of the transendothelial migration of neutrophils.
• Lou O, Alcaide P, Luscinskas FW, Muller WA Journal of immunology (Baltimore, Md. : 1950) 2007 Jan 15; 178(2):1136-43 PMID: 17202377
• NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion.
• Morandi B, Bougras G, Muller WA, Ferlazzo G, Münz C European journal of immunology 2006 Sep; 36(9):2394-400 PMID: 16917961
• Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis.
• Schenkel AR, Chew TW, Chlipala E, Harbord MW, Muller WA Experimental and molecular pathology 2006 Aug; 81(1):23-30 PMID: 16457810
• Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation.
• Han H, Roberts J, Lou O, Muller WA, Nathan N, Nathan C Journal of leukocyte biology 2006 Jan; 79(1):147-54 PMID: 16275893
• Transendothelial migration of monocytes: the underlying molecular mechanisms and consequences of HIV-1 infection.
• Maslin CL, Kedzierska K, Webster NL, Muller WA, Crowe SM Current HIV research 2005 Oct; 3(4):303-17 PMID: 16250878
• Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils.
• Han H, Stessin A, Roberts J, Hess K, Gautam N, Kamenetsky M, Lou O, Hyde E, Nathan N, Muller WA, Buck J, Levin LR, Nathan C The Journal of experimental medicine 2005 Aug 1; 202(3):353-61 PMID: 16043520

• Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
• Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Münz C Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 23; 101(47):16606-11 PMID: 15536127
• Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains.
• Schenkel AR, Chew TW, Muller WA Journal of immunology (Baltimore, Md. : 1950) 2004 Nov 15; 173(10):6403-8 PMID: 15528380
• Attenuation of leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine endotoxemia.
• Nolte D, Kuebler WM, Muller WA, Wolff KD, Messmer K European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 2004 Nov-Dec; 36(6):331-7 PMID: 15591740
• The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic.
• Ferlazzo G, Thomas D, Lin SL, Goodman K, Morandi B, Muller WA, Moretta A, Münz C Journal of immunology (Baltimore, Md. : 1950) 2004 Feb 1; 172(3):1455-62 PMID: 14734722
• The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection.
• Crowe S, Zhu T, Muller WA Journal of leukocyte biology 2003 Nov; 74(5):635-41 PMID: 12960232
• Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
• Muller WA Trends in immunology 2003 Jun; 24(6):327-34 PMID: 12810109
• Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.
• Burger PE, Coetzee S, McKeehan WL, Kan M, Cook P, Fan Y, Suda T, Hebbel RP, Novitzky N, Muller WA, Wilson EL Blood 2002 Nov 15; 100(10):3527-35 PMID: 12411316
• Leukocyte-endothelial cell interactions in the inflammatory response.
• Muller WA Laboratory investigation; a journal of technical methods and pathology 2002 May; 82(5):521-33 PMID: 12003992
• CD99 plays a major role in the migration of monocytes through endothelial junctions.
• Schenkel AR, Mamdouh Z, Chen X, Liebman RM, Muller WA Nature immunology 2002 Feb; 3(2):143-50 PMID: 11812991
• New mechanisms and pathways for monocyte recruitment.
• Muller WA The Journal of experimental medicine 2001 Nov 5; 194(9):F47-51 PMID: 11696603
• Eosinophil tissue recruitment to sites of allergic inflammation in the lung is platelet endothelial cell adhesion molecule independent.
• Miller M, Sung KL, Muller WA, Cho JY, Roman M, Castaneda D, Nayar J, Condon T, Kim J, Sriramarao P, Broide DH Journal of immunology (Baltimore, Md. : 1950) 2001 Aug 15; 167(4):2292-7 PMID: 11490017
• Inhibition of antigen-specific T cell trafficking into the central nervous system via blocking PECAM1/CD31 molecule.
• Qing Z, Sandor M, Radvany Z, Sewell D, Falus A, Potthoff D, Muller WA, Fabry Z Journal of neuropathology and experimental neurology 2001 Aug; 60(8):798-807 PMID: 11487054
• Binding of Plasmodium falciparum-infected erythrocytes to soluble platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): frequent recognition by clinical isolates.
• Heddini A, Chen Q, Obiero J, Kai O, Fernandez V, Marsh K, Muller WA, Wahlgren M The American journal of tropical medicine and hygiene 2001 Jul; 65(1):47-51 PMID: 11504407
• Migration of leukocytes across endothelial junctions: some concepts and controversies.
• Muller WA Microcirculation (New York, N.Y. : 1994) 2001 Jun; 8(3):181-93 PMID: 11498781
• Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability.
• Corada M, Liao F, Lindgren M, Lampugnani MG, Breviario F, Frank R, Muller WA, Hicklin DJ, Bohlen P, Dejana E Blood 2001 Mar 15; 97(6):1679-84 PMID: 11238107
• Putting the brakes on innate immunity: a regulatory role for CD200?
• Nathan C, Muller WA Nature immunology 2001 Jan; 2(1):17-9 PMID: 11135572

• The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes.
• Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ Cell 2000 Nov 22; 103(5):757-68 PMID: 11114332
• Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow.
• Allport JR, Muller WA, Luscinskas FW The Journal of cell biology 2000 Jan 10; 148(1):203-16 PMID: 10629229
• Assay for the transendothelial migration of human natural killer cells.
• Berman ME, Muller WA Methods in molecular biology (Clifton, N.J.) 2000; 121:115-23 PMID: 10818721
• Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo.
• Randolph GJ, Inaba K, Robbiani DF, Steinman RM, Muller WA Immunity 1999 Dec; 11(6):753-61 PMID: 10626897
• Transgenic mice expressing different levels of soluble platelet/endothelial cell adhesion molecule-IgG display distinct inflammatory phenotypes.
• Liao F, Schenkel AR, Muller WA Journal of immunology (Baltimore, Md. : 1950) 1999 Nov 15; 163(10):5640-8 PMID: 10553094
• Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes.
• Muller WA, Randolph GJ Journal of leukocyte biology 1999 Nov; 66(5):698-704 PMID: 10577496

• The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling.
• Thakker GD, Hajjar DP, Muller WA, Rosengart TK The Journal of biological chemistry 1999 Apr 9; 274(15):10002-7 PMID: 10187776
• Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.
• Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, Luis de la Pompa J, Elia A, Wakeham A, Karan-Tamir B, Muller WA, Senaldi G, Zukowski MM, Mak TW Journal of immunology (Baltimore, Md. : 1950) 1999 Mar 1; 162(5):3022-30 PMID: 10072554
• Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro.
• Randolph GJ, Luther T, Albrecht S, Magdolen V, Muller WA Blood 1998 Dec 1; 92(11):4167-77 PMID: 9834221
• Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking.
• Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA Science (New York, N.Y.) 1998 Oct 16; 282(5388):480-3 PMID: 9774276
• A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels.
• Randolph GJ, Beaulieu S, Pope M, Sugawara I, Hoffman L, Steinman RM, Muller WA Proceedings of the National Academy of Sciences of the United States of America 1998 Jun 9; 95(12):6924-9 PMID: 9618515
• Ligation of CD31/PECAM-1 modulates the function of lymphocytes, monocytes and neutrophils.
• Elias CG, Spellberg JP, Karan-Tamir B, Lin CH, Wang YJ, McKenna PJ, Muller WA, Zukowski MM, Andrew DP European journal of immunology 1998 Jun; 28(6):1948-58 PMID: 9645377
• Cell surface glycosaminoglycans do not serve as ligands for PECAM-1. PECAM-1 is not a heparin-binding protein.
• Sun QH, Paddock C, Visentin GP, Zukowski MM, Muller WA, Newman PJ The Journal of biological chemistry 1998 May 8; 273(19):11483-90 PMID: 9565561
• PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes.
• Treutiger CJ, Heddini A, Fernandez V, Muller WA, Wahlgren M Nature medicine 1997 Dec; 3(12):1405-8 PMID: 9396614
• Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.
• Ali J, Liao F, Martens E, Muller WA Microcirculation (New York, N.Y. : 1994) 1997 Jun; 4(2):267-77 PMID: 9219219
• Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation.
• Christofidou-Solomidou M, Nakada MT, Williams J, Muller WA, DeLisser HM Journal of immunology (Baltimore, Md. : 1950) 1997 May 15; 158(10):4872-8 PMID: 9144503

• Soluble domain 1 of platelet-endothelial cell adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro and in vivo.
• Liao F, Ali J, Greene T, Muller WA The Journal of experimental medicine 1997 Apr 7; 185(7):1349-57 PMID: 9104821
• Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1.
• Xie Y, Muller WA Genomics 1996 Oct 15; 37(2):226-8 PMID: 8921400
• Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation.
• Berman ME, Xie Y, Muller WA Journal of immunology (Baltimore, Md. : 1950) 1996 Feb 15; 156(4):1515-24 PMID: 8568255
• Assignment of PECAM1 to human chromosome bands 17q22-->q23 by in situ hybridization.
• Xie Y, Muller WA Cytogenetics and cell genetics 1996; 74(1-2):156 PMID: 8893826
• Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.
• Liao F, Huynh HK, Eiroa A, Greene T, Polizzi E, Muller WA The Journal of experimental medicine 1995 Nov 1; 182(5):1337-43 PMID: 7595204
• Isolation and longterm culture of human intestinal microvascular endothelial cells.
• Haraldsen G, Rugtveit J, Kvale D, Scholz T, Muller WA, Hovig T, Brandtzaeg P Gut 1995 Aug; 37(2):225-34 PMID: 7557573
• The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo.
• Muller WA Journal of leukocyte biology 1995 Apr; 57(4):523-8 PMID: 7722409
• Migration of leukocytes across the vascular intima molecules and mechanisms.
• Muller WA Trends in cardiovascular medicine 1995 Jan-Feb; 5(1):15-20 PMID: 21232233
• Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18).
• Berman ME, Muller WA Journal of immunology (Baltimore, Md. : 1950) 1995 Jan 1; 154(1):299-307 PMID: 7995949
• The use of anti-PECAM reagents in the control of inflammation.
• Muller WA Agents and actions. Supplements 1995; 46:147-57 PMID: 7610985
• Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.
• Bogen S, Pak J, Garifallou M, Deng X, Muller WA The Journal of experimental medicine 1994 Mar 1; 179(3):1059-64 PMID: 8113674
• Biochemical methods to determine cell-surface topography.
• Muller WA Methods in molecular biology (Clifton, N.J.) 1994; 27:31-42 PMID: 8298700
• Determination of cell-surface polarity by solid-phase lactoperoxidase iodination.
• Muller WA Methods in molecular biology (Clifton, N.J.) 1994; 27:19-30 PMID: 8298692
• PECAM-1 is required for transendothelial migration of leukocytes.
• Muller WA, Weigl SA, Deng X, Phillips DM The Journal of experimental medicine 1993 Aug 1; 178(2):449-60 PMID: 8340753
• Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans.
• DeLisser HM, Yan HC, Newman PJ, Muller WA, Buck CA, Albelda SM The Journal of biological chemistry 1993 Jul 25; 268(21):16037-46 PMID: 8340425
• Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1.
• Xie Y, Muller WA Proceedings of the National Academy of Sciences of the United States of America 1993 Jun 15; 90(12):5569-73 PMID: 8516303
• Monocyte-selective transendothelial migration: dissection of the binding and transmigration phases by an in vitro assay.
• Muller WA, Weigl SA The Journal of experimental medicine 1992 Sep 1; 176(3):819-28 PMID: 1512545
• A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31).
• Muller WA, Berman ME, Newman PJ, DeLisser HM, Albelda SM The Journal of experimental medicine 1992 May 1; 175(5):1401-4 PMID: 1569405
• Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants.
• Kumar R, Potvin B, Muller WA, Stanley P The Journal of biological chemistry 1991 Nov 15; 266(32):21777-83 PMID: 1718983
• Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.
• Albelda SM, Muller WA, Buck CA, Newman PJ The Journal of cell biology 1991 Sep; 114(5):1059-68 PMID: 1874786
• PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
• Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA Science (New York, N.Y.) 1990 Mar 9; 247(4947):1219-22 PMID: 1690453
• A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.
• Muller WA, Ratti CM, McDonnell SL, Cohn ZA The Journal of experimental medicine 1989 Aug 1; 170(2):399-414 PMID: 2666561
• Interleukin 2 receptors are expressed by alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine treatment of normal human lung macrophages, blood monocytes, and monocyte cell lines.
• Hancock WW, Muller WA, Cotran RS Journal of immunology (Baltimore, Md. : 1950) 1987 Jan 1; 138(1):185-91 PMID: 3097144
• Plasmalemmal proteins of cultured vascular endothelial cells exhibit apical-basal polarity: analysis by surface-selective iodination.
• Muller WA, Gimbrone MA The Journal of cell biology 1986 Dec; 103(6 Pt 1):2389-402 PMID: 3782302
• Infection within a degenerated Starr-Edwards silicone rubber poppet in the aortic valve position.
• Muller WA, Cohn LH, Schoen FJ The American journal of cardiology 1984 Nov 1; 54(8):1146 PMID: 6496341
• Intracellular iodination of lysosome membrane for studies of membrane composition and recycling.
• Muller WA, Steinman RM, Cohn ZA Methods in enzymology 1983; 98:404-15 PMID: 6669054
• Membrane proteins of the vacuolar system. III. Further studies on the composition and recycling of endocytic vacuole membrane in cultured macrophages.
• Muller WA, Steinman RM, Cohn ZA The Journal of cell biology 1983 Jan; 96(1):29-36 PMID: 6826650
• Endocytosis and the recycling of plasma membrane.
• Steinman RM, Mellman IS, Muller WA, Cohn ZA The Journal of cell biology 1983 Jan; 96(1):1-27 PMID: 6298247
• The membrane proteins of the vacuolar system I. Analysis of a novel method of intralysosomal iodination.
• Muller WA, Steinman RM, Cohn ZA The Journal of cell biology 1980 Jul; 86(1):292-303 PMID: 7419579
• The membrane proteins of the vacuolar system. II. Bidirectional flow between secondary lysosomes and plasma membrane.
• Muller WA, Steinman RM, Cohn ZA The Journal of cell biology 1980 Jul; 86(1):304-14 PMID: 7419580
• Retardation time measurementson replicating bacillus subtilis chromosomes: effect of EDTA concentration.
• Muller WA, Klotz LC Biochimica et biophysica acta 1975 Jan 20; 378(2):171-85 PMID: 804920