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Summary
Dr. Sergio Grinstein is a senior scientist in the The Hospital for Sick Children Research Institute, holder of the Pitblado Chair in Cell Biology at The Hospital for Sick Children (SickKids), and a professor of Biochemistry at the University of Toronto. He is internationally recognized for his research in two areas: the control of intracellular pH and the elucidation of mechanisms underlying the microbicidal response of macrophages and neutrophils.
Dr. Grinstein completed his PhD in 1976 at the Centro de Investigacion y Estudios Avanzados in Mexico City. He then spent two years as a postdoctoral fellow in Cell Biology at Sick Kids, followed by a year in the Department of Biochemistry at the Federal Institute of Technology in Zurich. He has been an International Scholar of the Howard Hughes Medical Institute and recipient of the Canadian Institutes of Health Research Distinguished Scientist Award, and is a Fellow of the Royal Society of Canada.
| Current Institution | University of Toronto |
| Department | Biochemistry |
| Disciplines | |
| Address | Hospital for Sick Children, McMaster Building, Room 5006 Toronto Ontario Canada Phone: 416-813-5727 |
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Education
Center for Research and Advanced Studies, Mexico
Ph.D.
(1976)
Work Experience
Professor of Biochemistry
University of Toronto
Achievements
General
Publication Summary
Publications
- Touret N, Paroutis P, Terebiznik M, Harrison R, Trinbetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore H-P, van der Wel Houben D, Peters PJ, de Chastellier C, Mellman I, Grinstein S. (2005) Quantitative and dynamic assessment of the contribution of the endoplasmic reticulum to phagosome formation. Cell. 2005 Oct 7;123(1):157-70.
- Alexander RT, Furuya W, Szaszi K, Orlowski J, Grinstein S. (2005) Rho GTPases dictate the mobility of the Na/H exchanger NHE3 in epithelia. role in apical retention and targeting. Proc. Nat. Acad. Sci. 102(34):12253-8
- Scott CC, Dobson W, Botelho RJ, Coady-Osberg N, Chavrier P, Knetch DA, Heath C, Stahl P, Grinstein S. (2005) sphatidylinositol-4,5 bisphosphate hydrolysis directs actin remodeling during phagocytosis. Cell Biol. 169:139-149.
- Jabado N, Cuellar-Mata P, Grinstein S, Gros P. (2003) Iron chelators modulate the fusogenic properties of salmonella containing phagosomes. Proc. Nat. Acad. Sci. 100:6127-6132.
- Touret N, Furuya W, Forbes J, Gros P, Grinstein, S. (2003) Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. J. Biol. Chem. 278:25548-25557.
- Vieira OT, Bucci C, Harrison RE, Trimble WS, Lanzetti L, Gruenberg J, Schreiber AD, Stahl PD, Grinstein S. (2003) Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol Cell Biol. 7:2501-14.
- Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S. (2003) Phagosomes fuse with lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP. Mol. Cell Biol 18:6494-6506.
- Brumell JH, Grinstein S. (2003) Role of lipid-mediated signal transduction in bacterial internalization. Cell. Microbiol. 5:287-297.
- Scott CC, Botelho RJ, Grinstein S. (2003) Phagosome maturation: a few bugs in the system. J. Memb. Biol. 193:137-152.
- Tse SML, Furuya W, Gold E, Schreiber AD, Sandvig K, Inman RD, Grinstein S. (2003) Differential role of actin, clathrin and dynamin in Fcγ receptor-mediated endocytosis and phagocytosis. J. Biol. Chem. 278:3331-3338.
- Szaszi K, Paulsen A, Szabo E, Numata M, Grinstein S, Orlowski J. (2002) Clathrin-mediated endocytosis and recycling of the neural-specific Na+/H+ exchanger NHE5 isoform: regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton. J. Biol. Chem. 277:42623-42632.
- Touret N, Grinstein S. (2002) Voltage-gated proton "channels": a spectator's viewpoint. J. Gen. Physiol. 120:767-771.
- Scott CC, Cuellar-Mata P, Matsuo T, Davidson HW, Grinstein S. (2002) Role of 3'-phosphoinositides in the maturation of Salmonella-containing vacuoles within host cells. J. Biol. Chem. 277:12770-12776.
- Hayashi H, Szaszi K, Coady-Osberg N, Orlowski J, Kinsella JL, Grinstein S. (2002) A slow pH-dependent conformational transition underlies a novel mode of activation of the epithelial Na+/H+ exchanger NHE3 isoform. J. Biol. Chem. 277:11090-11096.
- Terebiznik M, Vieira OV, Marcus S, Trimble WS, Meyer T, Finlay B, Grinstein S. (2002) Elimination of host cell PI(4,5)P2 by the bacterial phosphatase SopB/SigD promotes membrane fission during invasion by Salmonella. Nature Cell Biology 10:766-773.
- Harrison RE, Touret N, Grinstein S. (2002) Microbial killing: oxidants, proteases dispatch and ions. Curr. Biol. 10:R357-359.
- Booth JW, Kim M-K, Jankowski A, Schreiber A, Grinstein S. (2002) Contrasting requirements for ubiquitination during FcΥRIIA internalization by endocytosis versus phagocytosis. EMBO J. 21:251-258.
Books
Other Publications
