Summary
Paul Bryce, PhD, assistant professor of allergy-immunology and microbiology-immunology, grew up in the small town of Gourock, Scotland, where his family ran a local grocery store. He studied at the University of Strathclyde in Glascow, where he earned an undergraduate honors degree in immunology and pharmacology. During his undergraduate summers, Bryce worked with Sir James Black, who won a Nobel Prize in 1988 for his pharmacology research and drug discovery. After spending a short time at a pharmaceutical company, Bryce obtained a PhD from the University of Manchester under the mentorship of Ian Hutchinson, PhD, DSc. He moved to the United States in 1999 to pursue postdoc-toral work at Boston Children’s Hospital and became an instructor there in 2004. He came to Feinberg one year later.
| Current Institution | Northwestern University |
| Current School | Feinberg School of Medicine |
| Department | Medicine |
| Disciplines | |
| Address | McGaw Pavilion Suite M-316 240 E Huron Chicago Illinois 60611 United States Phone: 312/503-4000 |
Profile viewed 673 times
Publication Summary
Pubmed Publications
- Cutting Edge: Histamine Is Required for IL-4-Driven Eosinophilic Allergic Responses. Swartzendruber JA, Byrne AJ, Bryce PJ Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 9; : PMID: 22156496
- Regulatory T Cells Enhance Mast Cell Production of IL-6 via Surface-Bound TGF-ß Ganeshan K, Bryce PJ Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 9; : PMID: 22156492
- Expression of mast cell-associated genes is upregulated in adult eosinophilic esophagitis and responds to steroid or dietary therapy. Hsu Blatman KS, Gonsalves N, Hirano I, Bryce PJ The Journal of allergy and clinical immunology 2011 Feb 17; : PMID: 21333344
- IL-33 Is Produced by Mast Cells and Regulates IgE-Dependent Inflammation. Hsu CL, Neilsen CV, Bryce PJ PloS one 2010; 5(8):e11944 PMID: 20689814
- Antigen-Fixed Leukocytes Tolerize Th2 Responses in Mouse Models of Allergy. Smarr CB, Hsu CL, Byrne AJ, Miller SD, Bryce PJ Journal of immunology (Baltimore, Md. : 1950) 2011 Oct 5; : PMID: 21976774
- Linking air pollution exposure with thrombosis. Mutlu GM, Bryce PJ, Budinger GR Blood 2011 Sep 1; 118(9):2636-7 PMID: 21885614
- TLR-induced activation of neutrophils promotes histamine production via a PI3 kinase dependent mechanism. Smuda C, Wechsler JB, Bryce PJ Immunology letters 2011 Aug 30; : PMID: 21903133
- Revolution 9: the backwards and forwards evidence surrounding interleukin-9. Bryce PJ American journal of respiratory and critical care medicine 2011 Apr 1; 183(7):834-5 PMID: 21471072
- Legionella pneumophila Type II Secretion Dampens the Cytokine Response of Infected Macrophages and Epithelia. McCoy-Simandle K, Stewart CR, Dao J, Debroy S, Rossier O, Bryce PJ, Cianciotto NP Infection and immunity 2011 Mar 7; : PMID: 21383054
- New Developments in the Use of Histamine and Histamine Receptors. Smuda C, Bryce PJ Current allergy and asthma reports 2010 Nov 23; : PMID: 21104347
- Skin prick testing does not reflect the presence of IgE against food allergens in adult eosinophilic esophagitis patients: a case study. Kamdar TA, Ditto AM, Bryce PJ Clinical and molecular allergy : CMA 2010 Nov 17; 8(1):16 PMID: 21083924
- Immunotherapy in food allergy. Kamdar T, Bryce PJ Immunotherapy 2010 May; 2(3):329-38 PMID: 20543886
- Lck mediates Th2 differentiation through effects on T-bet and GATA-3. Kemp KL, Levin SD, Bryce PJ, Stein PL Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 15; 184(8):4178-84 PMID: 20237292
- Clinical reactivity to raw peanut correlates with IgE binding to conformational epitopes of Ara h 1: a Case Report. Ditto AM, Neilsen CV, Neerukonda S, Shreffler WG, Bryce PJ Allergy 2010 Apr 12; : PMID: 20412153 Two decades before the mast.
- Bryce P, Schleimer R American journal of respiratory cell and molecular biology 2010 Mar; 42(3):255-6 PMID: 20156978
- Interleukin-13 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils. Neilsen CV, Bryce PJ Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010 Mar; 40(3):427-34 PMID: 20030665
- Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS The Journal of allergy and clinical immunology 2009 Oct; 124(4):761-70.e1 PMID: 19815118
- Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. Tachdjian R, Mathias C, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, Chatila TA The Journal of experimental medicine 2009 Sep 28; 206(10):2191-204 PMID: 19770271
- Modeling food allergy: pathways to therapy. Bryce PJ Expert review of clinical immunology 2009 May; 5(3):225-8 PMID: 20476999
- Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. Berdnikovs S, Abdala-Valencia H, McCary C, Somand M, Cole R, Garcia A, Bryce P, Cook-Mills JM Journal of immunology (Baltimore, Md. : 1950) 2009 Apr 1; 182(7):4395-405 PMID: 19299740
- Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. Ganeshan K, Neilsen CV, Hadsaitong A, Schleimer RP, Luo X, Bryce PJ
- The Journal of allergy and clinical immunology 2009 Jan; 123(1):231-238.e4 PMID: 19022495
- Intranasal Aspergillus fumigatus exposure induces eosinophilic inflammation and olfactory sensory neuron cell death in mice. Epstein VA, Bryce PJ, Conley DB, Kern RC, Robinson AM Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2008 Mar; 138(3):334-9 PMID: 18312881
- TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation. Oyoshi MK, Bryce P, Goya S, Pichavant M, Umetsu DT, Oettgen HC, Tsitsikov EN Journal of immunology (Baltimore, Md. : 1950) 2008 Feb 1; 180(3):1878-85 PMID: 18209085
- Mast cell-derived histamine mediates cystitis pain. Rudick CN, Bryce PJ, Guichelaar LA, Berry RE, Klumpp DJ PLoS ONE 2008; 3(5):e2096 PMID: 18461160
- The H1 histamine receptor regulates allergic lung responses. Bryce PJ, Mathias CB, Harrison KL, Watanabe T, Geha RS, Oettgen HC The Journal of clinical investigation 2006 Jun; 116(6):1624-32 PMID: 16680192
- TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45. Bryce PJ, Oyoshi MK, Kawamoto S, Oettgen HC, Tsitsikov EN International immunology 2006 Jan; 18(1):101-11 PMID: 16352630
- Antigen-independent effects of immunoglobulin E. Bryce PJ, Oettgen HC Current allergy and asthma reports 2005 May; 5(3):186-90 PMID: 15842955
- Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells. Bryce PJ, Miller ML, Miyajima I, Tsai M, Galli SJ, Oettgen HC Novartis Foundation symposium 2005; 271:15-24; discussion 24-38, 95-9 PMID: 16605126
- The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. Kawamoto S, Yalcindag A, Laouini D, Brodeur S, Bryce P, Lu B, Humbles AA, Oettgen H, Gerard C, Geha RS The Journal of clinical investigation 2004 Aug; 114(3):399-407 PMID: 15286806
- Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Alonzi T, Newton IP, Bryce PJ, Di Carlo E, Lattanzio G, Tripodi M, Musiani P, Poli V Cytokine 2004 Apr 21; 26(2):45-56 PMID: 15050604
- Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Bryce PJ, Miller ML, Miyajima I, Tsai M, Galli SJ, Oettgen HC Immunity 2004 Apr; 20(4):381-92 PMID: 15084268
- Impaired IgA class switching in APRIL-deficient mice. Castigli E, Scott S, Dedeoglu F, Bryce P, Jabara H, Bhan AK, Mizoguchi E, Geha RS Proceedings of the National Academy of Sciences of the United States of America 2004 Mar 16; 101(11):3903-8 PMID: 14988498
- IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. Gurish MF, Bryce PJ, Tao H, Kisselgof AB, Thornton EM, Miller HR, Friend DS, Oettgen HC Journal of immunology (Baltimore, Md. : 1950) 2004 Jan 15; 172(2):1139-45 PMID: 14707089
- Epicutaneous sensitization with superantigen induces allergic skin inflammation. Laouini D, Kawamoto S, Yalcindag A, Bryce P, Mizoguchi E, Oettgen H, Geha RS The Journal of allergy and clinical immunology 2003 Nov; 112(5):981-7 PMID: 14610492
- Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. Blaeser F, Bryce PJ, Ho N, Raman V, Dedeoglu F, Donaldson DD, Geha RS, Oettgen HC, Chatila TA The Journal of experimental medicine 2003 Oct 20; 198(8):1189-200 PMID: 14557412
- IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. Laouini D, Alenius H, Bryce P, Oettgen H, Tsitsikov E, Geha RS The Journal of clinical investigation 2003 Oct; 112(7):1058-66 PMID: 14523043
- Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. Bryce PJ, Geha R, Oettgen HC The Journal of allergy and clinical immunology 2003 Jul; 112(1):149-58 PMID: 12847492
- CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. Ma W, Bryce PJ, Humbles AA, Laouini D, Yalcindag A, Alenius H, Friend DS, Oettgen HC, Gerard C, Geha RS The Journal of clinical investigation 2002 Mar; 109(5):621-8 PMID: 11877470
- Immunomodulatory effects of pharmacological elevation of cyclic AMP in T lymphocytes proceed via a protein kinase A independent mechanism. Bryce PJ, Dascombe MJ, Hutchinson IV Immunopharmacology 1999 Feb; 41(2):139-46 PMID: 10102795
- Differences in the mode of action of cyclosporine and FK 506. Hutchinson IV, Bagnall W, Bryce P, Pufong B, Geraghty P, Brogan I Transplantation proceedings 1998 Jun; 30(4):959-60 PMID: 9636388
Books
Other Publications

