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Summary
I am interested in the genetic basis of heritable traits. The genetic basis of most traits is complex, involving many genes that interact with each other and the environment. My lab conducts experiments in model organisms (the yeast Saccharomyces cerevisiae and the nematode worm Caenorhabditis elegans), as well as computational analyses, aimed at understanding how changes at the level of DNA are shaped by molecular and evolutionary forces, and how these changes lead to all the observable differences among individuals within a species.
| Current Institution | Princeton University |
| Department | Ecology&Evolutionary |
| Disciplines | |
| Address | 143 Carl C. Icahn Laboratory Princeton New Jersey United States Phone: 609-258-9209 |
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Education
University of California, Berkeley
Ph.D,
Physics
(1990)
University of California, Berkeley
M.A,
Physics
(1989)
Work Experience
Professor
Princeton University
(2005 - Present)
Associated Faculty
Princeton University
(2005 - Present)
Achievements
General
Publication Summary
Selected Publications
- Torabi N, Kruglyak L. (2011) Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae. PLoS Genet. 7: e1002211.
- Seidel HS, Ailion M, Li J, van Oudenaarden A, Rockman MV, Kruglyak L. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. PLoS Biol. 9: e1001115.
- Ehrenreich IM, Torabi N, Jia Y, Kent J, Martis S, Shapiro JA, Gresham D, Caudy AA, Kruglyak L. (2010) Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature. 464: 1039-1042.
- Gresham D, Curry B, Ward A, Gordon DB, Brizuela L, Kruglyak L, Botstein D. (2010) Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proc Natl Acad Sci. 107: 1482-1487.
- Ehrenreich IM, Gerke JP, Kruglyak L. (2009) Genetic dissection of complex traits in yeast: Insights from studies of gene expression and other phenotypes in the BYxRM cross. Cold Spring Harb Symp Quant Biol. 74: 145-153.
- Khan Z, Bloom JS, Garcia BA, Singh M, Kruglyak L. (2009) Protein quantification across hundreds of experimental conditions. Proc Natl Acad Sci. 106: 15544-15548.
- Bloom JS, Khan Z, Kruglyak L, Singh M, Caudy AA. (2009) Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics 10: 221.
- Khan Z, Bloom JS, Kruglyak L, Singh M. (2009) A practical algorithm for finding maximal exact matches in large sequence data sets using sparse suffix arrays. Bioinformatics. 25: 1609-1616.
- Rockman MV, Kruglyak L. (2009) Recombinational landscape and population genomics of Caenorhabditis elegans. PLoS Genet. 5: e1000419.
- Schacherer J, Shapiro JA, Ruderfer DM, Kruglyak L. (2009) Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature 458: 342-345.
- Capra EJ, Skrovanek SM, Kruglyak L. (2008) Comparative developmental expression profiling of two C. elegans isolates. PLoS ONE. 3: e4055.
- Coller HA, Kruglyak L. (2008) Genetics. It's the sequence, stupid! Science 322: 380-381.
- Gresham D, Kruglyak L. (2008) Rise of the machines. PLoS Genet. 4: e1000134.
- Rockman MV, Kruglyak L. (2008) Breeding designs for recombinant inbred advanced intercross lines. Genetics 179: 1069-1078.
- Smith EN, Kruglyak L. (2008) Gene-environment interaction in yeast gene expression. PLoS Biol. 6: e83.
- Kruglyak L. (2008) The road to genome-wide association studies. Nat Rev Genet. 9: 314-318.
- Seidel HS, Rockman MV, Kruglyak L. (2008) Widespread genetic incompatibility in C. Elegans maintained by balancing selection. Science 319: 589-594.
- Kruglyak L, Stern DL. (2007) Evolution. An embarrassment of switches. Science 317: 758-759.
- Schacherer J, Ruderfer DM, Gresham D, Dolinski K, Botstein D, Kruglyak L. (2007) Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. PLoS ONE 2: e322.
- Rockman MV, Kruglyak L. (2006) Genetics of global gene expression. Nat Rev Genet 7: 862-782.
- Ruderfer DM, Pratt SC, Seidel HS, Kruglyak L. (2006) Population genomic analysis of outcrossing and recombination in yeast. Nat Genet 38: 1077-1081.
- Gresham D, Ruderfer DM, Pratt SC, Schacherer J, Dunham MJ, Botstein D, Kruglyak L. (2006) Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science 311: 1932-1936.
- Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. (2006) Revealing complex traits with small molecules and naturally recombinant yeast strains. Chem Biol 13: 319-327.
- Ronald J, Brem RB, Whittle J, Kruglyak L. (2005) Local regulatory variation in Saccharomyces cerevisiae. PLoS Genet 1: e25.
- Brem RB, Storey JD, Whittle J, Kruglyak L. (2005) Genetic interactions between polymorphisms that affect gene expression in yeast. Nature 436: 701-703.
- Storey JD, Akey JM, Kruglyak L. (2005) Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol 3: e267.
- Ronald J, Akey JM, Whittle J, Smith EN, Yvert G, Kruglyak L. (2005) Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res 15: 284-291.
- Brem RB, Kruglyak L. (2005) The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci USA 102: 1572-1577.
- Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. (2004) Genetic structure of the purebred domestic dog. Science 304: 1160-1164.
- Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L. (2004) Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol 2: e286.
- Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. (2003) Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet 35: 57-64.
- Niare O, Markianos K, Volz J, Oduol F, Toure A, Bagayoko M, Sangare D, Traore SF, Wang R, Blass C, Dolo G, Bouare M, Kafatos FC, Kruglyak L, Toure YT, Vernick KD. (2002) Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population. Science 298: 213-296.
- Brem RB, Yvert G, Clinton R, Kruglyak L. (2002) Genetic dissection of transcriptional regulation in budding yeast. Science 296: 752-755.
Books
Other Publications
