PubMed Publications

• Voltage-dependent calcium signaling in rat cerebellar unipolar brush cells.
• Birnstiel S, Slater NT, McCrimmon DR, Mugnaini E, Hartell NA Neuroscience 2009 Sep 1; 162(3):702-12 PMID: 19409228
• The chemical neuroanatomy of breathing.
• Alheid GF, McCrimmon DR Respiratory physiology & neurobiology 2008 Dec 10; 164(1-2):3-11 PMID: 18706532
• Central pathways of pulmonary and lower airway vagal afferents.
• Kubin L, Alheid GF, Zuperku EJ, McCrimmon DR Journal of applied physiology (Bethesda, Md. : 1985) 2006 Aug; 101(2):618-27 PMID: 16645192
• Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region.
• Ptak K, Zummo GG, Alheid GF, Tkatch T, Surmeier DJ, McCrimmon DR The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 May 25; 25(21):5159-70 PMID: 15917456
• Turning the PAGe on Central Control of the Exercise Pressor Reflex in Humans.
• Alheid GF, Iwamoto GA, Thomas JX, McCrimmon DR Journal of applied physiology (Bethesda, Md. : 1985) 2011 Jan 20; : PMID: 21252220
• Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.
• Mutlu GM, Budinger GR, Green AA, Urich D, Soberanes S, Chiarella SE, Alheid GF, McCrimmon DR, Szleifer I, Hersam MC Nano letters 2010 May 12; 10(5):1664-70 PMID: 20377197
• Overview: the neurochemistry of respiratory control.
• McCrimmon DR, Mitchell GS, Alheid GF Respiratory physiology & neurobiology 2008 Dec 10; 164(1-2):1-2 PMID: 18721910
• Reflexively inhibiting respiratory drive.
• McCrimmon DR, Alheid GF The Journal of physiology 2007 Apr 1; 580(Pt 1):3 PMID: 17317738
• The rhombencephalon and breathing: a view from the pons.
• McCrimmon DR, Milsom WK, Alheid GF Respiratory physiology & neurobiology 2004 Nov 15; 143(2-3):103-4 PMID: 15519547
• Pontine influences on breathing: an overview.
• Alheid GF, Milsom WK, McCrimmon DR Respiratory physiology & neurobiology 2004 Nov 15; 143(2-3):105-14 PMID: 15519548
• Parabrachial-lateral pontine neurons link nociception and breathing.
• Jiang M, Alheid GF, Calandriello T, McCrimmon DR Respiratory physiology & neurobiology 2004 Nov 15; 143(2-3):215-33 PMID: 15519557
• Capra, eupnea, dyspnea, apnea: respiratory rhythms and the pre-Bötzinger complex in the goat.
• McCrimmon DR, Alheid GF Journal of applied physiology (Bethesda, Md. : 1985) 2004 Nov; 97(5):1618-9 PMID: 15475553
• Resurgent Na currents in four classes of neurons of the cerebellum.
• Afshari FS, Ptak K, Khaliq ZM, Grieco TM, Slater NT, McCrimmon DR, Raman IM Journal of neurophysiology 2004 Nov; 92(5):2831-43 PMID: 15212420
• Neonatal stress alters adult breathing.
• McCrimmon DR, Alheid GF The Journal of physiology 2004 Feb 1; 554(Pt 3):591 PMID: 14673182
• Converging functional and anatomical evidence for novel brainstem respiratory compartments in the rat.
• McCrimmon DR, Alheid GF, Jiang M, Calandriello T, Topgi A Advances in experimental medicine and biology 2004; 551:101-5 PMID: 15602950
• Concept mapping in pulmonary physiology using pathfinder scaling.
• McGaghie WC, McCrimmon DR, Mitchell G, Thompson JA Advances in health sciences education : theory and practice 2004; 9(3):225-40 PMID: 15316273
• Intrinsic bursting activity in the pre-Bötzinger complex: role of persistent sodium and potassium currents.
• Rybak IA, Shevtsova NA, Ptak K, McCrimmon DR Biological cybernetics 2004 Jan; 90(1):59-74 PMID: 14762725
• On the opiate trail of respiratory depression.
• McCrimmon DR, Alheid GF American journal of physiology. Regulatory, integrative and comparative physiology 2003 Dec; 285(6):R1274-5 PMID: 14615398
• Sodium currents in neurons from the rostroventrolateral medulla of the rat.
• Rybak IA, Ptak K, Shevtsova NA, McCrimmon DR Journal of neurophysiology 2003 Sep; 90(3):1635-42 PMID: 12761275
• Defining ventral medullary respiratory compartments with a glutamate receptor agonist in the rat.
• Monnier A, Alheid GF, McCrimmon DR The Journal of physiology 2003 May 1; 548(Pt 3):859-74 PMID: 12640009
• Short-term plasticity of descending synaptic input to phrenic motoneurons in rats.
• Hayashi F, Hinrichsen CF, McCrimmon DR Journal of applied physiology (Bethesda, Md. : 1985) 2003 Apr; 94(4):1421-30 PMID: 12482770
• Differential processing of excitation by GABAergic gain modulation in canine caudal ventral respiratory group neurons.
• Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ Journal of neurophysiology 2003 Feb; 89(2):862-70 PMID: 12574464
• Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat.
• Alheid GF, Gray PA, Jiang MC, Feldman JL, McCrimmon DR Journal of neurocytology 2002 Sep-Nov; 31(8-9):693-717 PMID: 14501208
• Gain modulation of respiratory neurons.
• Zuperku EJ, McCrimmon DR Respiratory physiology & neurobiology 2002 Jul; 131(1-2):121-33 PMID: 12107000
• Respiratory rhythm generation: converging concepts from in vitro and in vivo approaches?
• Ramirez JM, Zuperku EJ, Alheid GF, Lieske SP, Ptak K, McCrimmon DR Respiratory physiology & neurobiology 2002 Jul; 131(1-2):43-56 PMID: 12106994
• Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.
• Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA, McCrimmon DR, Zuperku EJ Journal of neurophysiology 2001 Nov; 86(5):2363-73 PMID: 11698526
• Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons.
• Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL Nature neuroscience 2001 Sep; 4(9):927-30 PMID: 11528424
• Respiratory rhythm generation: preBötzinger neuron discharge patterns and persistent sodium current.
• McCrimmon DR, Monnier A, Ptak K, Zummo G, Zhang Z, Alheid GF Advances in experimental medicine and biology 2001; 499:147-52 PMID: 11729869

• Relative magnitude of tonic and phasic synaptic excitation of medullary inspiratory neurons in dogs.
• Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ American journal of physiology. Regulatory, integrative and comparative physiology 2000 Aug; 279(2):R639-49 PMID: 10938255
• Quantitative concept mapping in pulmonary physiology: comparison of student and faculty knowledge structures.
• McGaghie WC, McCrimmon DR, Mitchell G, Thompson JA, Ravitch MM Advances in physiology education 2000 Jun; 23(1):72-81 PMID: 10902530
• Medical and veterinary students' structural knowledge of pulmonary physiology concepts.
• McGaghie WC, McCrimmon DR, Thompson JA, Ravitch MM, Mitchell G Academic medicine : journal of the Association of American Medical Colleges 2000 Apr; 75(4):362-8 PMID: 10893120

• Pattern formation and rhythm generation in the ventral respiratory group.
• McCrimmon DR, Monnier A, Hayashi F, Zuperku EJ Clinical and experimental pharmacology & physiology 2000 Jan-Feb; 27(1-2):126-31 PMID: 10696541
• Unraveling the mechanism for respiratory rhythm generation.
• McCrimmon DR, Ramirez JM, Alford S, Zuperku EJ BioEssays : news and reviews in molecular, cellular and developmental biology 2000 Jan; 22(1):6-9 PMID: 10649284
• Differential roles of ionotropic glutamate receptors in canine medullary inspiratory neurons of the ventral respiratory group.
• Krolo M, Stuth EA, Tonkovic-Capin M, Dogas Z, Hopp FA, McCrimmon DR, Zuperku EJ Journal of neurophysiology 1999 Jul; 82(1):60-8 PMID: 10400935
• Differential effects of GABAA receptor antagonists in the control of respiratory neuronal discharge patterns.
• Dogas Z, Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ Journal of neurophysiology 1998 Nov; 80(5):2368-77 PMID: 9819249
• Modulation of the synaptic drive to respiratory premotor and motor neurons.
• McCrimmon DR, Zuperku EJ, Hayashi F, Dogas Z, Hinrichsen CF, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA Respiration physiology 1997 Nov; 110(2-3):161-76 PMID: 9407609
• Respiratory neurons mediating the Breuer-Hering reflex prolongation of expiration in rat.
• Hayashi F, Coles SK, McCrimmon DR The Journal of neuroscience : the official journal of the Society for Neuroscience 1996 Oct 15; 16(20):6526-36 PMID: 8815930
• Respiratory motor responses to cranial nerve afferent stimulation in rats.
• Hayashi F, McCrimmon DR The American journal of physiology 1996 Oct; 271(4 Pt 2):R1054-62 PMID: 8898000
• Learning pulmonary physiology: comparison of student and faculty knowledge structures.
• McGaghie WC, Boerger RL, McCrimmon DR, Ravitch MM Academic medicine : journal of the Association of American Medical Colleges 1996 Jan; 71(1 Suppl):S13-5 PMID: 8546769
• NMDA receptor-mediated transmission of carotid body chemoreceptor input to expiratory bulbospinal neurones in dogs.
• Dogas Z, Stuth EA, Hopp FA, McCrimmon DR, Zuperku EJ The Journal of physiology 1995 Sep 15; 487 ( Pt 3):639-51 PMID: 8544127

• Agreement among medical experts about the structure of concepts in pulmonary physiology.
• McGaghie WC, Boerger RL, McCrimmon DR, Ravitch MM Academic medicine : journal of the Association of American Medical Colleges 1994 Oct; 69(10 Suppl):S78-80 PMID: 7916837
• Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebellate rats.
• Hayashi F, Coles SK, Bach KB, Mitchell GS, McCrimmon DR The American journal of physiology 1993 Oct; 265(4 Pt 2):R811-9 PMID: 8238451
• Pulmonary stretch receptor afferents activate excitatory amino acid receptors in the nucleus tractus solitarii in rats.
• Bonham AC, Coles SK, McCrimmon DR The Journal of physiology 1993 May; 464:725-45 PMID: 8229827
• Neurones in a discrete region of the nucleus tractus solitarius are required for the Breuer-Hering reflex in rat.
• Bonham AC, McCrimmon DR The Journal of physiology 1990 Aug; 427:261-80 PMID: 2213599
• Slow excitatory amino acid receptor-mediated synaptic transmission in turtle cerebellar Purkinje cells.
• Larson-Prior LJ, McCrimmon DR, Slater NT Journal of neurophysiology 1990 Mar; 63(3):637-50 PMID: 1970354
• Involvement of excitatory amino acids in neurotransmission of inspiratory drive to spinal respiratory motoneurons.
• McCrimmon DR, Smith JC, Feldman JL The Journal of neuroscience : the official journal of the Society for Neuroscience 1989 Jun; 9(6):1910-21 PMID: 2542482
• Cardiovascular function is altered by picomole injections of glutamate into rat medulla.
• Nelson DO, Cohen HL, Feldman JL, McCrimmon DR The Journal of neuroscience : the official journal of the Society for Neuroscience 1988 May; 8(5):1684-93 PMID: 2896765
• Role of the ventrolateral region of the nucleus of the tractus solitarius in processing respiratory afferent input from vagus and superior laryngeal nerves.
• McCrimmon DR, Speck DF, Feldman JL Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1987; 67(3):449-59 PMID: 3653307
• Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brain stem.
• McCrimmon DR, Feldman JL, Speck DF The Journal of neuroscience : the official journal of the Society for Neuroscience 1986 Aug; 6(8):2384-92 PMID: 2875138
• Effect of synchronous activation of medullary inspiratory bulbo-spinal neurones on phrenic nerve discharge in cat.
• Feldman JL, McCrimmon DR, Speck DF The Journal of physiology 1984 Feb; 347:241-54 PMID: 6707958
• Monoamine neurotransmitter metabolism during acclimatization to hypoxia in rats.
• Olson EB, Vidruk EH, McCrimmon DR, Dempsey JA Respiration physiology 1983 Oct; 54(1):79-96 PMID: 6139854

• Effect of catecholamine depletion on ventilatory control in unanesthetized normoxic and hypoxic rats.
• McCrimmon DR, Dempsey JA, Olson EB Journal of applied physiology: respiratory, environmental and exercise physiology 1983 Aug; 55(2):522-8 PMID: 6618945
• Inhibition of respiratory neural discharges by clonidine and 5-hydroxytryptophan.
• McCrimmon DR, Lalley PM The Journal of pharmacology and experimental therapeutics 1982 Sep; 222(3):771-7 PMID: 6286937 Serotonin and the control of ventilation in awake rats.
• Olson EB, Dempsey JA, McCrimmon DR The Journal of clinical investigation 1979 Aug; 64(2):689-93PMID: 156738

• Cardiovascular response to interval and continuous training in women.
• European journal of applied physiology and occupational physiology 1979 Jul 2; 41(3):187-97 PMID: 488084
• Effect of training on plasma catecholamines in post myocardial infarction patients.
• McCrimmon DR, Cunningham DA, Rechnitzer PA, Griffiths J Medicine and science in sports 1976 Fall; 8(3):152-6 PMID: 979560

Other Publications

• Computational modeling of bursting pacemaker neurons in the pre-Bötzinger complex Shevtsova N.A., Ptak K., McCrimmon D.R., Rybak I.A. Neurocomputing 2003 Jun; 52-54:933-942

Books and Book Chapters

• Feldman JL, McCrimmon DR. Chapter 37: Neural Control of Breathing. In: Squire LR, Berg D, Bloom FE, Du Lac S, Ghosh A, Spitzer NC, editors. 2008. Fundamental Neuroscience, 3rd edition. New York: Academic Press 855-872.
• Mitchell G.S., McCrimmon D.R., Feldman J.L., Baker-Herman T.L.. Control of breathing: chemoreception, neuroplasticity, integrated responses and disorders of ventilatory control. In: Squire L.R., editor. 2009. Encyclopedia of Neuroscience.. Oxford U.K.: Academic Press 121-130.
• McCrimmon D.R., Mitchell G.S., Feldman J.L., Alheid G.F. Network control. In: Squire L.R., editor. 2009. Encyclopedia of Neuroscience.. Oxford U.K.: Academic Press 79-89.
• Feldman J.L., McCrimmon D.R., Mitchell G.S., Del Negro C.A. Generation of respiratory rhythm in mammals. In: Squire L.R., editor. 2009. Encyclopedia of Neuroscience.. Oxford U.K.: Academic Press 463-470.
• McCrimmon D.R., Alheid G.F. Respiratory reflexes. In: Binder M.D., Hirokawa N., Windhorst U., editors. 2009. Encyclopedia of Neuroscience. Berlin: Springer-Verlag
• Alheid G.F., McCrimmon D.R. Anatomy and function in the respiratory network. In: Binder M.D., Hirokawa N., Windhorst U., editors. 2009. The Encyclopedia of Neuroscience. Berlin: Springer-Verlag
• McCrimmon D.R., Alheid G.F., Zuperku E.J.. Reflexes from the lungs and chest wall. In: Laurent G.J., Shapiro S.D., editors. 2006. Encyclopedia of Respiratory Medicine. Oxford U.K.: Academic Press 618-625.
• Feldman JL, McCrimmon DR. Chapter 37: Neural control of breathing. In: Squire LR, Bloom FE, McConnell SK, Roberts JL, Spitzer NC, Zigmond MJ, editors. 2003. Fundamental Neuroscience. New York: Academic Press 967-990.
• Feldman JL, McCrimmon DR. Chapter 40: Neural Control of Breathing. In: Bloom FE, Landis SC, Roberts JL, Squire LC, Zigmond MJ, editors. 1999. Neural Control of Breathing. New York: Academic Press 1063-1090.
• McCrimmon DR, Mitchell GS, Dekin M. Glutamate, GABA and Serotonin in Ventilatory Control. In: Dempsey JA, Pack A, editors. 1995. Lung Biology in Health and Disease. Regulation of Breathing. New York: Marcel Dekker 151-218.
• McCrimmon DR, Bonham AC, Coles SK. Production of the Breuer-Hering reflex in the rat requires excitatory amino acid transmission in a discrete region of the nucleus tractus solitarius. In: Speck DF, Dekin MS, Revelette WR, Frazier DT, editors. 1993. Respiratory Control. Central and Peripheral Mechanisms. Lexington, KY: University Press of Kentucky 86-90.
• Feldman JL, Smith JC, McCrimmon DR, Ellenberger HH, Speck DF. Generation of respiratory patterns in mammals. In: Cohen AH, Rossignol S, Grillner S, editors. 1988. Neural Control of Rhythmic Movements in Vertebrates. New York: Wiley and Sons 73-100.
• McCrimmon DR, Feldman JL. Central Nervous System Pharmacology of the Control of Breathing. In: Sieck GC, Gandevia SC, Cameron WE, editors. 1987. Respiratory Muscles and Their Neuromotor Control. New York: Alan R Liss 37-47.
• McCrimmon DR, Feldman JL, Speck DF, Ellenberger HH, Smith JC. Functional heterogeneity of dorsal, ventral and pontine respiratory groups revealed by micropharmacological techniques. In: von Euler C, Lagercrantz H, editors. 1987. Neurobiology of the Control of Breathing. Karolinska Institute Nobel Conference Series. New York: Raven Press 201-208.
• Feldman JL, McCrimmon DR, Smith JC, Ellenberger HH, Speck DF. Role of the dorsal respiratory group (DRG): Processing of vagal and superior laryngeal nerve afferent input. In: von Euler C, Lagercrantz H, editors. 1987. Neurobiology of the Control of Breathing. Karolinska Institute Nobel Conference Series. New York: Raven Press 157-164.
• McCrimmon DR, Speck DF, Feldman JL. Role of the dorsal respiratory group (DRG): Processing of vagal and superior laryngeal nerve afferent input. In: Bianchi AL, Denavit-Saubié M, editors. 1985. Neurogenesis of Central Respiratory Rhythm Electrophysiological Pharmacological and Pathological Aspects. Lancaster: MTP Press 254-257.
• Feldman JL, McCrimmon DR, Speck DF. Role of the dorsal and ventral respiratory groups: Generation of spatiotemporal patterns of motoneuronal activity. In: Bianchi AL, Denavit-Saubié M, editors. 1985. Neurogenesis of Central Respiratory Rhythm Electrophysiological Pharmacological and Pathological Aspects. Lancaster: MTP Press 121-125.
• Speck DF, McCrimmon DR, Feldman JL. Role of the dorsal and ventral respiratory groups: Generation of respiratory rhythm. In: Bianchi AL, Denavit-Saubié M, editors. 1985. Neurogenesis of Central Respiratory Rhythm. Electrophysiological Pharmacological and Pathological Aspects. Lancaster: MTP Press 126-129.