Publications

• Molecular determinants of ciliary membrane localization of Trypanosoma cruzi flagellar calcium-binding protein. Maric D, McGwire BS, Buchanan KT, Olson CL, Emmer BT, Epting CL, Engman DM. J Biol Chem. 2011 Sep 23;286(38):33109-17. Epub 2011 Jul 22. PMID: 21784841
• Gene profiling for assessment of cell-based therapies. Engman DM. Cell Cycle. 2011 Jul 1;10(13):2054. Epub 2011 Jul 1. No abstract available. PMID: 21701260
• Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunity. Bonney KM, Taylor JM, Daniels MD, Epting CL, Engman DM. PLoS One. 2011 Jan 21;6(1):e14571. Erratum in: PLoS One. 2011;6(2). doi:10.1371/annotation/118b702e-9609-4f91-afba-6a76f8f1f14a. PMID: 21283741
• Global analysis of protein palmitoylation in African trypanosomes. Emmer BT, Nakayasu ES, Souther C, Choi H, Sobreira TJ, Epting CL, Nesvizhskii AI, Almeida IC, Engman DM. Eukaryot Cell. 2011 Mar;10(3):455-63. Epub 2010 Dec 30. PMID: 21193548
• Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. de Paulo Martins V, Okura M, Maric D, Engman DM, Vieira M, Docampo R, Moreno SN. J Biol Chem. 2010 Oct 1;285(40):30906-17. Epub 2010 Jul 20. PMID: 2064731
• Molecular mechanisms of host cell invasion by Trypanosoma cruzi. Epting CL, Coates BM, Engman DM. Exp Parasitol. 2010 Nov;126(3):283-91. Epub 2010 Jun 18. Review. Erratum in: Exp Parasitol. 2011 Feb;127(2):607. PMID: 20599990
• Composition and sensory function of the trypanosome flagellar membrane. Maric D, Epting CL, Engman DM. Curr Opin Microbiol. 2010 Aug;13(4):466-72. Epub 2010 Jun 30. Review. PMID: 20580599
• Calflagin inhibition prolongs host survival and suppresses parasitemia in Trypanosoma brucei infection. Emmer BT, Daniels MD, Taylor JM, Epting CL, Engman DM. Eukaryot Cell. 2010 Jun;9(6):934-42. Epub 2010 Apr 23. PMID: 20418379
• Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs. Brass LF, Akabas MH, Burnley LD, Engman DM, Wiley CA, Andersen OS. Acad Med. 2010 Apr;85(4):692-701. PMID: 20186033
• Molecular mechanisms of protein and lipid targeting to ciliary membranes. Emmer BT, Maric D, Engman DM. J Cell Sci. 2010 Feb 15;123(Pt 4):529-36. Review. PMID: 20145001
• Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection. Kulkarni MM, Olson CL, Engman DM, McGwire BS. Infect Immun. 2009 May;77(5):2193-200. Epub 2009 Mar 9. PMID: 19273559
• Flagellar membrane localization via association with lipid rafts. Tyler KM, Fridberg A, Toriello KM, Olson CL, Cieslak JA, Hazlett TL, Engman DM. J Cell Sci. 2009 Mar 15;122(Pt 6):859-66. Epub 2009 Feb 24. PMID: 19240119
• Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane. Emmer BT, Souther C, Toriello KM, Olson CL, Epting CL, Engman DM. J Cell Sci. 2009 Mar 15;122(Pt 6):867-74. Epub 2009 Feb 24. PMID: 19240115
• Chagas heart disease pathogenesis: one mechanism or many? Bonney KM, Engman DM. Curr Mol Med. 2008 Sep;8(6):510-8. Review. PMID: 18781958
• Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity. Daniels MD, Hyland KV, Wang K, Engman DM. Autoimmunity. 2008 Sep;41(6):490-9. PMID: 18781477
• Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi. Wingard JN, Ladner J, Vanarotti M, Fisher AJ, Robinson H, Buchanan KT, Engman DM, Ames JB. J Biol Chem. 2008 Aug 22;283(34):23388-96. Epub 2008 Jun 17. PMID: 18559337
• Bioluminescent imaging of Trypanosoma cruzi infection. Hyland KV, Asfaw SH, Olson CL, Daniels MD, Engman DM. Int J Parasitol. 2008 Oct;38(12):1391-400. Epub 2008 Apr 25. PMID: 18511053
• Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. Fridberg A, Olson CL, Nakayasu ES, Tyler KM, Almeida IC, Engman DM. J Cell Sci. 2008 Feb 15;121(Pt 4):522-35. Epub 2008 Jan 29. PMID: 18230649
• Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. Bahk TJ, Daniels MD, Leon JS, Wang K, Engman DM. Int J Cardiol. 2008 Mar 28;125(1):85-93. Epub 2007 Jun 22. PMID: 17588693
• Treatment of experimental myocarditis via modulation of the renin-angiotensin system. Daniels MD, Hyland KV, Engman DM. Curr Pharm Des. 2007;13(13):1299-305. Review. PMID: 17506715
• Modulation of autoimmunity by treatment of an infectious disease. Hyland KV, Leon JS, Daniels MD, Giafis N, Woods LM, Bahk TJ, Wang K, Engman DM. Infect Immun. 2007 Jul;75(7):3641-50. Epub 2007 May 7. PMID: 17485457
• The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing. Kulkarni MM, McMaster WR, Kamysz E, Kamysz W, Engman DM, McGwire BS. Mol Microbiol. 2006 Dec;62(5):1484-97. Epub 2006 Oct 27. PMID: 17074074
• Flagellar membrane trafficking in kinetoplastids. Fridberg A, Buchanan KT, Engman DM. Parasitol Res. 2007 Jan;100(2):205-12. Epub 2006 Oct 21. Review. PMID: 17058110
• Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry. Cunha-Neto E, Bilate AM, Hyland KV, Fonseca SG, Kalil J, Engman DM. Autoimmunity. 2006 Feb;39(1):41-54. Review. PMID: 16455581
• Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease. Hyland KV, Engman DM. Trends Parasitol. 2006 Mar;22(3):101-2; author reply 103. Epub 2006 Jan 30. PMID: 16446117
• Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression. Croxford JL, Wang K, Miller SD, Engman DM, Tyler KM. Cell Microbiol. 2005 Nov;7(11):1592-602. PMID: 16207246
• Responsive microtubule dynamics promote cell invasion by Trypanosoma cruzi. Tyler KM, Luxton GW, Applewhite DA, Murphy SC, Engman DM. Cell Microbiol. 2005 Nov;7(11):1579-91. PMID: 16207245
• A flagellum-specific calcium sensor. Buchanan KT, Ames JB, Asfaw SH, Wingard JN, Olson CL, Campana PT, Araújo AP, Engman DM. J Biol Chem. 2005 Dec 2;280(48):40104-11. Epub 2005 Sep 7. PMID: 16148003
• A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins. Leon JS, Daniels MD, Toriello KM, Wang K, Engman DM. Infect Immun. 2004 Jun;72(6):3410-7. PMID: 15155647
• Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease. Leon JS, Wang K, Engman DM. J Immunol. 2003 Oct 15;171(8):4271-7. PMID: 14530351
• Killing of African trypanosomes by antimicrobial peptides. McGwire BS, Olson CL, Tack BF, Engman DM. J Infect Dis. 2003 Jul 1;188(1):146-52. Epub 2003 Jun 16. PMID: 12825184
• Captopril prevents experimental autoimmune myocarditis. Godsel LM, Leon JS, Wang K, Fornek JL, Molteni A, Engman DM. J Immunol. 2003 Jul 1;171(1):346-52. PMID: 12817017
• Captopril ameliorates myocarditis in acute experimental Chagas disease. Leon JS, Wang K, Engman DM. Circulation. 2003 May 6;107(17):2264-9. Epub 2003 Apr 21. PMID: 12707246
• A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi. Verbisck NV, dos Santos MR, Engman DM, Angel Chiurillo M, Ramirez JL, Araya JE, Mortara RA, da Silveira JF. Mem Inst Oswaldo Cruz. 2003 Jan;98(1):129-33. Epub 2003 Apr 9. PMID: 12700870
• The significance of autoimmunity in the pathogenesis of Chagas heart disease. Leon JS, Engman DM. Front Biosci. 2003 May 1;8:e315-22. Review. PMID: 12700038
• Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists in experimental myocarditis. Godsel LM, Leon JS, Engman DM. Curr Pharm Des. 2003;9(9):723-35. Review. PMID: 12570790
• Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63. McGwire BS, Chang KP, Engman DM. Infect Immun. 2003 Feb;71(2):1008-10. PMID: 12540585
• Pathogenesis of Chagas heart disease: role of autoimmunity. Engman DM, Leon JS. Acta Trop. 2002 Feb;81(2):123-32. Review. PMID: 11801219
• Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence. McGwire BS, O'Connell WA, Chang KP, Engman DM. J Biol Chem. 2002 Mar 15;277(11):8802-9. Epub 2002 Jan 2. PMID: 11777912
• Cardiac myosin autoimmunity in acute Chagas' heart disease. Leon JS, Godsel LM, Wang K, Engman DM. Infect Immun. 2001 Sep;69(9):5643-9. PMID: 11500440
• Autoimmunity in Chagas heart disease. Leon JS, Engman DM. Int J Parasitol. 2001 May 1;31(5-6):555-61. Review. PMID: 11334942
• The life cycle of Trypanosoma cruzi revisited. Tyler KM, Engman DM. Int J Parasitol. 2001 May 1;31(5-6):472-81. Review. PMID: 11334932
• Prevention of autoimmune myocarditis through the induction of antigen-specific peripheral immune tolerance. Godsel LM, Wang K, Schodin BA, Leon JS, Miller SD, Engman DM. Circulation. 2001 Mar 27;103(12):1709-14. PMID: 11274001
• Flagellar elongation induced by glucose limitation is preadaptive for Trypanosoma cruzi differentiation. Tyler KM, Engman DM. Cell Motil Cytoskeleton. 2000 Aug;46(4):269-78. PMID: 10962481
• Identification of calcium binding sites in the trypanosome flagellar calcium-acyl switch protein. Maldonado RA, Mirzoeva S, Godsel LM, Lukas TJ, Goldenberg S, Watterson DM, Engman DM. Mol Biochem Parasitol. 1999 Jun 25;101(1-2):61-70. PMID: 10413043
• Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism. Godsel LM, Engman DM. EMBO J. 1999 Apr 15;18(8):2057-65. PMID: 10205160
• TcDJ1, a putative mitochondrial DnaJ protein in Trypanosoma cruzi. Carreira MA, Tibbetts RS, Olson CL, Schuster C, Renz M, Engman DM, Goldenberg S. FEMS Microbiol Lett. 1998 Sep 1;166(1):141-6. PMID: 9741092
• The DnaJ family of protein chaperones in Trypanosoma cruzi. Tibbetts RS, Jensen JL, Olson CL, Wang FD, Engman DM. Mol Biochem Parasitol. 1998 Mar 15;91(2):319-26. PMID: 9566524
• Human antibody responses to Trypanosoma cruzi 70-kD heat-shock proteins. Krautz GM, Peterson JD, Godsel LM, Krettli AU, Engman DM. Am J Trop Med Hyg. 1998 Feb;58(2):137-43. PMID: 9502594
• Homologues of the 24-kDa flagellar Ca(2+)-binding protein gene of Trypanosoma cruzi are present in other members of the Trypanosomatidae family. Maldonado RA, Linss J, Thomaz N, Olson CL, Engman DM, Goldenberg S. Exp Parasitol. 1997 Jul;86(3):200-5. PMID: 9225770
• Molecular comparison of the mitochondrial and cytoplasmic hsp70 of Trypanosoma cruzi, Trypanosoma brucei and Leishmania major. Klein KG, Olson CL, Donelson JE, Engman DM. J Eukaryot Microbiol. 1995 Sep-Oct;42(5):473-6. PMID: 7581323
• Utility of recombinant flagellar calcium-binding protein for serodiagnosis of Trypanosoma cruzi infection. Godsel LM, Tibbetts RS, Olson CL, Chaudoir BM, Engman DM. J Clin Microbiol. 1995 Aug;33(8):2082-5. PMID: 7559952
• Trypanosoma cruzi: accumulation of polycistronic hsp70 RNAs during severe heat shock. Engman DM, Henkle-Dührsen K, Kirchhoff LV, Donelson JE. Exp Parasitol. 1995 May;80(3):575-7. No abstract available. PMID: 7729493
• A rapid method for protein localization in trypanosomes. Tibbetts RS, Klein KG, Engman DM. Exp Parasitol. 1995 May;80(3):572-4. No abstract available. PMID: 7537220
• Comparison of the 24 kDa flagellar calcium-binding protein cDNA of two strains of Trypanosoma cruzi. Godsel LM, Olson CL, Lacava ZG, Engman DM. J Eukaryot Microbiol. 1995 May-Jun;42(3):320-2. PMID: 7496390
• Mitochondrial heat shock protein 70 is distributed throughout the mitochondrion in a dyskinetoplastic mutant of Trypanosoma brucei. Klein KG, Olson CL, Engman DM. Mol Biochem Parasitol. 1995 Mar;70(1-2):207-9. PMID: 7637705
• Trypanosoma cruzi heat-shock protein 90 can functionally complement yeast. Palmer G, Louvion JF, Tibbetts RS, Engman DM, Picard D. Mol Biochem Parasitol. 1995 Mar;70(1-2):199-202. PMID: 7637703
• Expression and localization of Trypanosoma cruzi hsp60. Sullivan MA, Olson CL, Winquist AG, Engman DM. Mol Biochem Parasitol. 1994 Dec;68(2):197-208. PMID: 7739666
• Molecular cloning and characterization of the 78-kilodalton glucose-regulated protein of Trypanosoma cruzi. Tibbetts RS, Kim IY, Olson CL, Barthel LM, Sullivan MA, Winquist AG, Miller SD, Engman DM. Infect Immun. 1994 Jun;62(6):2499-507. PMID: 8188375
• Molecular and biochemical comparison of the 70-kDa heat shock proteins of Trypanosoma cruzi. Olson CL, Nadeau KC, Sullivan MA, Winquist AG, Donelson JE, Walsh CT, Engman DM. J Biol Chem. 1994 Feb 4;269(5):3868-74. PMID: 8106432
• Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice. Tibbetts RS, McCormick TS, Rowland EC, Miller SD, Engman DM. J Immunol. 1994 Feb 1;152(3):1493-9. PMID: 8301148
• A mitochondrial heat shock protein from Crithidia fasciculata. Effron PN, Torri AF, Engman DM, Donelson JE, Englund PT. Mol Biochem Parasitol. 1993 Jun;59(2):191-200. PMID: 8341318
• 83-kilodalton heat shock proteins of trypanosomes are potent peptide-stimulated ATPases. Nadeau K, Sullivan MA, Bradley M, Engman DM, Walsh CT. Protein Sci. 1992 Aug;1(8):970-9. PMID: 1304385
• Specific functional domains of mitochondrial hsp70s suggested by sequence comparison of the trypanosome and yeast proteins. Engman DM, Fehr SC, Donelson JE. Mol Biochem Parasitol. 1992 Mar;51(1):153-5. No abstract available. PMID: 1565130
• The gene family encoding eggshell proteins of Schistosoma japonicum. Henkle KJ, Cook GA, Foster LA, Engman DM, Bobek LA, Cain GD, Donelson JE. Mol Biochem Parasitol. 1990 Aug;42(1):69-82. PMID: 2172818
• Human humoral immunity to hsp70 during Trypanosoma cruzi infection. Engman DM, Dragon EA, Donelson JE. J Immunol. 1990 May 15;144(10):3987-91. PMID: 2110215
• Comparison of HSP70 genes from two strains of Trypanosoma cruzi. Engman DM, Sias SR, Gabe JD, Donelson JE, Dragon EA. Mol Biochem Parasitol. 1989 Dec;37(2):285-7. PMID: 2691890
• A novel flagellar Ca2+-binding protein in trypanosomes. Engman DM, Krause KH, Blumin JH, Kim KS, Kirchhoff LV, Donelson JE. J Biol Chem. 1989 Nov 5;264(31):18627-31. PMID: 2681200
• Molecular cloning of mtp70, a mitochondrial member of the hsp70 family. Engman DM, Kirchhoff LV, Donelson JE. Mol Cell Biol. 1989 Nov;9(11):5163-8. PMID: 2689873
• Ubiquitin genes in trypanosomatidae. Kirchhoff LV, Kim KS, Engman DM, Donelson JE. J Biol Chem. 1988 Sep 5;263(25):12698-704. PMID: 2457589
• Trypanosoma cruzi exhibits inter- and intra-strain heterogeneity in molecular karyotype and chromosomal gene location. Engman DM, Reddy LV, Donelson JE, Kirchhoff LV Mol Biochem Parasitol. 1987 Jan 15;22(2-3):115-23. PMID: 3553931
• The 35-nucleotide spliced leader sequence is common to all trypanosome messenger RNA's. Walder JA, Eder PS, Engman DM, Brentano ST, Walder RY, Knutzon DS, Dorfman DM, Donelson JE. Science. 1986 Aug 1;233(4763):569-71. PMID: 3523758