Our laboratory pioneered in pancreas tissue slices approach to study the function of insulin-secreting beta cells in mice in 2001 (Speier and Rupnik, 2003; Rupnik 2009). Soon after the tissue slice approach has been extended to assess the perinatal development of the endocrine pancreas (Meneghel-Rozzo et al., 2004; Rozzo et al., 2009), normal and diabetic rats (Rose at al., 2007) as well as to establish the function of insulin-producing stem cells (Blyszczuk et al., 2005). Furthermore, using...
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